Magne Sydnes

Head of Department, University of Bergen

magne.sydnes@uib.no

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Presentation Title

Development of Photodegradable Pharmaceuticals

Presentation Abstract

Accumulation of persistent pharmaceuticals in the environment after use is a growing problem worldwide with consequences for the health of the environment as well as human health.1 We have for some time been working on developing chemistry that facilitates quicker degradation of active pharmaceutical ingredients (APIs) after use.2-5 With emphasis on development of antimicrobial agents the talk will focus on the rational behind the concept, current status, and future use of photodegradable pharmaceuticals.

  1. Brodin, T. et al. The urgent need for designing greener drugs. Nature Sustainability 2024, https://www.nature.com/articles/s41893-024-01374-y
  2. Eikemo, V.; Sydnes, L. K.; Sydnes, M. O. Photodegradable antimicrobial agents – synthesis, photodegradation, and biological evaluation. RSC Adv. 2021, 11, 32339-32345.
  3. Eikemo, V.; Holmelid, B.; Sydnes, L. K.; Sydnes, M. O. Photodegradable Antimicrobial Agents – Synthesis and Mechanism of Degradation. J. Org. Chem. 2022, 87, 8034-8047.
  4. Sydnes, M. O.; Eikemo, V.; Espedal, P. G.; Leiv K. Sydnes, and Frank Nilsen – Evaluation of Photodegradable Chitin Synthetase Inhibitors for the Treatment of Salmon Lice (Lepeophtheirus salmonis). Aquaculture 2023, 569, 739372.
  5. de Aquino, G. A. S.; Sang, L. N. V.; Valery, R.; Lanave, M.; Estopiñá-Durán, S.; Håheim, K. S.; Ferreira, S. B.; Sydnes, M. O. Photodegradable Antimicrobial Agents: Towards Structure Optimization. RSC Adv. 2023, 13, 29729-29734.

About Magne

Magne O. Sydnes was born in Oslo, Norway in 1973. He received his MSc degree in synthetic organic chemistry from the University of Oslo in 1998. After a short stint in industry he commenced his PhD studies in 2001 at the Australian National University, Canberra, under the guidance of Professor Banwell. Since earning his PhD in 2004 he has been working as a postdoctoral fellow both in Australia and Japan, including two years as a JSPS postdoctoral fellow in Professor Isobe’s group at Nagoya University, Japan. In 2009 he joined International Research Institute of Stavanger, Norway, as a researcher. Since December 2011 he has been at University of Stavanger, Norway. He is now the institute leader at the department of chemistry at the University of Bergen.