Description of Research Group
Post transcriptional regulation of mRNAs is a key aspect of gene expression. Whether a particular mRNA is translated, repressed, or degraded, depends on its interactions with a variety of RNA-binding
proteins and regulatory RNAs. We are interested in elucidating how these interactions determine mRNA fates and how post transcriptional mechanisms control fundamental biological processes. Our research has important biomedical implications for human disorders, including obesity and cancer. Our main experimental models are the nematode Caenorhabditis elegans, which has the advantage of a genetically tractable organism , and mammalian cells . Our interdisciplinary approach combines genetics and genomics with molecular biology, throuqh biochemistrv and structural biology.
Technology, expertise and equipment
- Various molecular and biochemical approaches to analyzing RNA regulation.
- Molecular genetics.
- General genomics, like RNA seq, polymorphism mapping etc.
- C.elegans transgenics with appropriate instrumentation.